Figure 5.

Side‐effects and excretion of astatine‐211 (²¹¹At) in a mouse model of peritoneal metastasis of gastric cancer treated with ²¹¹At‐labeled trastuzumab (²¹¹At‐tras). (a) Bodyweight of the mice after treatment. Plots were interrupted if the animal reached the defined endpoint. Data represent mean ± SD. (b) White blood cell counts in the mice after treatment. Plots were interrupted if the animal reached the defined endpoint. Data represent mean ± SD . (c) ²¹¹At levels in feces and urine of the mice up to 24 h after i.p. injection of ²¹¹At‐tras (1 MBq). Six mice were used in the experiment. The bars represent the cumulative mean values obtained over a 24‐h observation period. Bars are labeled in the graph. (d) Glutamic oxaloacetic transaminase (GOT; red), glutamic pyruvate transaminase (GPT; blue), and blood urea nitrogen (BUN; green) values up to 14 days after i.p. injection of ²¹¹At‐tras (1 MBq). Five mice were used for 0 and 1 days, and four mice were used for 7 and 14 days. Data for each mouse are shown in the graph.