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. 2017 Jun 14;108(8):1544–1555. doi: 10.1111/cas.13281

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Overexpression of ArfGAP with SH3 domain, ankyrin repeat, and PH domain 3 (ASAP3) was correlated with poor survival in patients with colorectal cancer (CRC). (a, b) ASAP3 expression was significantly increased in CRC tumor tissues when compared with normal tissues from The Cancer Genome Atlas (TCGA) and Renji datasets (P < 0.0001). (c) Statistical analysis of ASAP3 protein expression in normal and CRC tissues as determined by immunohistochemistry (IHC) (n = 90; P < 0.0001). (d) Representative images of ASAP3 expression in 90 paired normal and cancerous colon tissues by IHC analysis from Renji Hospital (Shanghai, China). (e) Kaplan–Meier survival analysis of CRC patients stratified by ASAP3 expression level. (f) Receiver operating characteristic curves for survival prediction using ASAP3 level (left panel), American Joint Committee on Cancer (AJCC) stage (middle panel), or a combination of the two factors (right panel). The area under the curve (AUC) and the corresponding 95% confidence intervals (CI) are shown in the plots.