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. 2017 Jun 20;152(1):65–73. doi: 10.1111/imm.12749

Figure 4.

Figure 4

Killer cell lectin‐like receptor G1 (KLRG1) reduces regulatory T (Treg) cell competitive fitness in the gut (a) Frequencies of CD4+ and Foxp3+ among CD4+ cells in KLRG1 knockout (KO) or control mixed bone marrow chimeras 6 months after reconstitution. KLRG1 KO or KLRG1‐sufficient control bone marrow (both CD45.2+) was mixed with CD45.1+ bone marrow and injected into irradiated CD45.1+ recipients. Mice were analysed 6 months after reconstitution. Horizontal bars represent arithmetical mean. (b) Frequencies of KLRG1 KO (filled symbols) or control (empty symbols) CD45.2+ chimerism among CD4+ Foxp3− and CD4+ Foxp3+ cells in the bone marrow chimeras shown in (a). Comparison refers to frequency of CD45.2+ cells in the two different chimeras, CD45.2+ cells are either KLRG1 KO or control‐derived. Each point corresponds to an individual mouse. Horizontal bars represent arithmetic mean. Data are representative of three independent experiments. ***P < 0·001; **P < 0·01; *P < 0·05; ns, not significant.