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. 2017 Jul 3;108(8):1620–1627. doi: 10.1111/cas.13297

Figure 5.

Figure 5

Rab25 is responsible for RIN1‐induced EGFR signaling and tumor malignancy in clear cell renal cell carcinoma (ccRCC) cell. (a) Western blotting shows that after treatment of siRab25 or AG1478 (10 μM) in NC65‐RIN1 cells, the levels of p‐EGFR, p‐AKT and p‐ERK decreased. (b) Transfection of siRab25 or treatment of AG1478 into NC65‐RIN1 cells abrogated proliferation, as determined by MTT assay. (c) The invasive ability of NC65‐RIN1 cells was dramatically inhibited after siRab25 or AG1478 treatment in a transwell assay. (d) Wound‐healing assays show that the enhanced migration ability in NC65‐RIN1 cells was inhibited by silence of Rab25 or AG1478 treatment.