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. 2017 Feb 28;21(8):1619–1635. doi: 10.1111/jcmm.13091

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Mice with Vil‐Cre;Pkd2 ^f3/f3 alleles mimic the cystic phenotypes of human ADPKD. Compared to age‐matched control mice (A–C), 4‐month‐old Vil‐Cre;Pkd2 ^f3/f3 mice showed massive gross cysts (arrows) in the kidneys (D), liver (E) and pancreas (F). (G) H&E staining of a section from the kidney shown in (D). (H) The same H&E staining for the control kidney shown in (A). (I) Kaplan–Meier survival curves for Vil‐Cre;Pkd2 ^f3/f3 mice. The median survival time for Vil‐Cre;Pkd2 ^f3/f3 mice was about 4.5 months. Bars: 5 mm in A–F; 1 mm in G and H.