Table 4.
Receptor repertoire diversity indices
| Shannon's entropy | Gini–Simpson's evenness | Simpson's diversity | Top 100/total clonotypes | |
|---|---|---|---|---|
| TRG | ||||
| Patient | 5·27 | 0·960 | 25 | 0·57 |
| HD1 | 7·20 | 0·999 | 893 | 0·20 |
| HD2 | 6·30 | 0·994 | 177 | 0·44 |
| IGH | ||||
| Patient | 6·33 | 0·997 | 295 | 0·51 |
| HD1 | 7·38 | 0·999 | 894 | 0·19 |
| HD2 | 7·25 | 0·999 | 802 | 0·21 |
Shannon's entropy is a measurement of the richness and diversity of a repertoire, whereas Gini–Simpson's, Simpson's and Top 100 clonotypes provide different views into clone frequency distribution within a repertoire. HD = healthy donor.