Figure 7.

There is a trend towards decreased mucosal‐associated invariant T cell (MAIT) frequency in patients receiving vitamin D and free‐serum 25‐hydroxyvitamin D (s25OHD) correlates positively with CD38 expression by these cells. At baseline, free‐s25OHD was correlated positively with CD38 expression, P = 0·008, (a) and tended to correlate with human leucocyte antigen D‐related (HLA‐DR) expression, P = 0·055, (b) by MAIT cells. MAIT cells were identified by the combined expression of CD161 and Vα7.2 by T cells (c). There was a trend towards decreased MAIT cell frequency at the end of intervention compared with baseline in the combined group of patients receiving vitamin D2 or D3, P = 0·0506 (d). At the end of intervention, the change in free‐s25OHD was correlated negatively with the change in CD279 (programmed death 1) expression on MAIT cells (e). P < 0·05 in all, unless stated otherwise. Results are plotted as raw data from all subjects participating in the study irrespective of treatment arm (a,b,e) and as raw data from the subjects in the pooled vitamin D2 and vitamin D3 treatment group (d). The number of patients presented in the individual graphs varies due to a few missing samples (see Table 3).