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. 2017 Jun 20;152(1):125–137. doi: 10.1111/imm.12754

Figure 6.

Figure 6

Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) expression on regulatory T (Treg) cells prevents autoimmune attack on tissue. (a) Arthritis score (left) and incidence (right) of wild‐type (WT) MMC + or MMC − and inducible conditional knockout (iCKO) MMC + or MMC − mice that were CTLA‐4 depleted at the boost, days 35, 36, 40. (b) interferon‐γ (IFN‐γ) T‐cell response against unmodified (K264) or galactosylated (GalHy264) collagen type‐II (CII) peptides, after deduction of RPMI medium response, determined by ELISPOT from pooled draining lymph node and spleen cells on day 77 after immunization. (c) Total anti‐CII antibody titres in serum of WT MMC + or MMC − and iCKO MMC + or MMC − mice depleted at the boost. (d) Visual summary of the role of CTLA‐4 expression on conventional T (Tconv) and Treg cells towards heterologous and autologous CII‐peptides in collagen‐induced arthritis. Error bars represent mean ± SEM.