Figure 3.

Native immunoglobulin (Ig)G complexes complexes expose sialic acids and O‐glycosidically linked (β1–3) galactose and N‐acetylgalactosamine (GalNAc‐L) detected by lectin enzyme‐linked immunosorbent assay (ELISA). Circulating native IgG complexes from patients with RA exhibit significantly increased binding of Sambucus nigra agglutinin (SNA) compared to normal healthy donors (NHD). This was increased even 36 months after start of therapy. The reactivity of native IgG complexes with GalNAc‐L compared to NHD was significantly higher for patients at inclusion and decreased significantly after 3 years of therapy. Shown are optical density (OD) values assessed by capture ELISA and the significances are presented after Bonferroni correction.