Table 1.
Comparison of the clinical characteristics of SI-NENs among different races
| Characteristics | Chinese Patients (N = 277) |
SEER database | P value | ||
|---|---|---|---|---|---|
| White patients (N = 6711) | Black patients (N = 1387) | Asian/Pacific Islander Patients (N = 217) | |||
| Age, years | <0.001 | ||||
| Mean(95%CI) | 54.4 (52.8–56.0) | 62.4 (62.0–62.7) | 60.3 (59.6–61.0) | 60.7 (59.0–62.5) | |
| Range | 17–83 | 2–98 | 21–96 | 27–95 | |
| Sex | <0.001 | ||||
| Male | 157 (56.7%) | 3448 (51.4%) | 635 (45.8%) | 116 (53.5%) | |
| Female | 120 (43.3%) | 3263 (48.6%) | 752 (54.2%) | 101 (46.5%) | |
| Location of primary tumora | <0.001 | ||||
| Duodenum | 212b (76.5%) | 1541 (31.9%) | 569 (57.5%) | 123 (71.9%) | |
| ampulla | 72 (37.1%) | 117 (7.6%) | 24 (4.2%) | 9 (7.3%) | |
| Non-ampulla | 122 (62.9%) | 1424 (92.4%) | 545 (95.8%) | 114 (92.7%) | |
| Jejunum/ileum | 65 (23.5%) | 3283 (68.1%) | 420 (42.5%) | 48 (28.1%) | |
| Presenting Symptoms | - | ||||
| Abdominal pain | 152 (54.9%) | ||||
| Nausea/vomiting | 48 (17.3%) | ||||
| Bloating | 42 (15.2%) | ||||
| Jaundice | 37 (13.4%) | ||||
| GI bleeding | 34 (12.3%) | ||||
| Diarrhea | 27 (9.7%) | ||||
| Intestinal obstruction | 24 (8.7%) | ||||
| Flushing | 9 (3.2%) | ||||
| Incidental diagnosis | - | ||||
| Yes | 35 (12.6%) | ||||
| No (symptomatic) | 242 (87.4%) | ||||
| Tumor sizec | <0.001 | ||||
| Median (cm) | 2.5 | 1.6 | 1.5 | 1.5 | |
| Tumor graded | - | ||||
| Grade 1 | 91 (36.5%) | ||||
| Grade 2 | 81 (32.5%) | ||||
| Grade 3 | 77 (30.9%) | ||||
| Tumor differentiatione | 0.095f | ||||
| Well differentiated | 2324 (76.6%) | 474 (81.3%) | 69 (74.2%) | ||
| Moderately differentiated | 553 (18.2%) | 84 (14.4%) | 15 (16.1%) | ||
| Poorly differentiated/undifferentiated | 157 (5.2%) | 25 (4.3%) | 9 (9.7%) | ||
| Tumor stageg | <0.001h | ||||
| I | 32 (13.3%) | 626 (13.2%) | 162 (18.3%) | 43 (25.4%) | |
| II | 88 (36.5%) | 709 (15.0%) | 186 (21.0%) | 28 (16.6%) | |
| III | 61 (25.3%) | 2077 (43.8%) | 331 (37.4%) | 59 (34.9%) | |
| IV | 60 (24.9%) | 1329 (28.0%) | 205 (23.2%) | 39 (23.1%) | |
| Location of distant metastasesi | - | ||||
| No | 217 (78.3%) | ||||
| Liver | 52 (86.7%) | ||||
| Bone | 3 (5.0%) | ||||
| Lung | 1 (1.7%) | ||||
| Brain | 1 (1.7%) | ||||
| Others | 13 (21.7%) | ||||
| Surgery of primary tumor | - | ||||
| Performed | 233 (84.1%) | 5787 (86.2%) | 1097 (79.1%) | 166 (76.5%) | |
| Unperformed or unknown | 44 (15.9%) | 924 (13.8%) | 290 (20.9%) | 51 (23.5%) | |
GI gastrointestinal. aThe specific location of 1887 white patients, 398 black patients and 46 Asian/Pacific Islander patients from SEER database were not available. bIn Chinese patients, the specific location of 18 patients with duodenal NENs was unknown. cTumor size was specified in 222 Chinese patients, 5249 white patients, 1008 black patients and 151 Asian/Pacific Islander patients from SEER database. dTumor grade based on WHO grading criteria was specified in 249 Chinese patients. eIn SEER database series, tumor differentiation was available in 3034 white patients, 583 black patients and 93 Asian/Pacific Islander patients. fWell/moderately differentiated and poorly differentiated/undifferentiated were compared among different races. gTumor stage was specified in 241 Chinese patients, 4741 white patients, 884 black patients and 169 Asian/Pacific Islander patients from SEER database. hStage I/II and stage III/IV were compared among different races. iInformation of location of distant metastases was available in all Chinese patients