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. 2017 Aug 4;17:521. doi: 10.1186/s12885-017-3490-3

Table 4.

Univariate and multivariate analysis of overall survival in patients with SI-NENs: comparison of Ki-67 index 2 and 5% as threshold

Factor (N) Univariate analysis Multivariate analysis
2% as threshold 5% as threshold
HR (95% CI) P HR (95% CI) P HR (95% CI) P
Age (207) 1.02 (0.99–1.04) 0.204
Sex 0.502
 Male (121) 1.00
 Female (86) 0.82 (0.45–1.48)
Location of primary tumor
 Ampulla (54) 1.00
 Non-ampulla duodenum (106) 0.69 (0.35–1.34) 0.272
 Jejunum/ileum (47) 0.62 (0.29–1.34) 0.223
Tumor stage 0.002 0.022 0.033
 Stage I/II (95) 1.00 1.00 1.00
 Stage III (44) 2.43 (1.01–5.87) 0.048 1.89 (0.78–4.58) 0.158 1.90 (0.79–4.61) 0.155
 Stage IV (48) 4.68 (2.13–10.27) <0.001 3.44 (1.55–7.62) 0.002 3.29 (1.48–7.31) 0.003
 Unknown (20) 2.90 (1.03–8.15) 0.044 2.26 (0.80–6.37) 0.124 2.17 (0.77–6.13) 0.144
Ki-67 index <0.001 <0.001
  ≤ 2% (80) 1.00 1.00
 3%–20% (63) 2.67 (0.82–8.68) 0.102 2.18 (0.66–7.15) 0.199
  > 20% (64) 14.73 (5.20–41.74) <0.001 12.21 (4.26–34.98) <0.001
Ki-67 index <0.001 <0.001
  ≤ 5% (118) 1.00 1.00
 6%–20% (25) 4.29 (1.44–12.76) 0.009 3.28 (1.08–9.98) 0.036
  > 20% (64) 12.98 (5.70–29.56) <0.001 11.31 (4.92–26.01) <0.001