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PI3K/Akt/mTOR pathway is essential to tanshinone IIA-mediated protective effects in OGD/R-mediated HT-22 cell death. The CCK-8 assay showed that tanshinone IIA treatment increased the viability of HT-22 cells in OGD/R model, but this effect was abrogated by mTOR siRNA, Akt siRNA transfection or LY294002 treatment. **p<0.01.
