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. 2017 May;14(2):132–140. doi: 10.2174/1567202614666170306105315

Fig. (9).

Fig. (9)

Effect of PI3K/Akt/mTOR pathway on tanshinone IIA-reduced autophagy in HT-22 cells. The mTOR siRNA, Akt siRNA transfection or LY294002 treatment increased expression of LC3 II in the presence of tanshinone IIA, which suggests tanshinone IIA inhibited autophagy was dependent on the PI3K/Akt/mTOR pathway. Representative photographs of fluorescence (A). Western-blots analysis (B) Scale bar represents 50 µm.