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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Cell Metab. 2017 Jul 5;26(1):94–109. doi: 10.1016/j.cmet.2017.06.016

Figure 1. T cell anti-tumor therapies.

Figure 1

There are several clinical techniques that have been utilized to harness the immune system to treat cancer. (A) In some instances, T cells are isolated from the peripheral blood of the patient and genetically transduced to express a chimeric antigen receptor (CAR) or T cell receptor (TCR) that confers the ability to specifically recognize and destroy tumor cells when re-infused into the patient. (B) Another technique is the adoptive transfer of anti-tumor T cells that were isolated from within a patient’s tumor. Tumor-specific T cells are extracted from resected tumor samples, then expanded in vitro, followed by re-infusion into the patient and administration of the T cell growth factor IL-2.