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IP3 release in the cochlear sensory epithelium by osmolarity stress and mechanical stimulation. The cochlea was preincubated in normal extracellular solution (300 mOsm) and then switched to be incubated in a hypotonic extracellular solution (275 mOsm). The IP3 release was increased by the hypotonic challenge and blocked by cotreatment with 0.1 mM CBX.
