Table 3.
Liver dose volume histogram (DVH) data for all patient as well as the two patients who experienced G5 hepatic toxicity
| All patients Median (range) | Patient 1a | Patient 2b | Goal/Constraint | |
|---|---|---|---|---|
| Uninvolved liver volume | 1550 cc (917 –3556) | 1980 cc | 1400 cc | |
| GTV volume | 107 (16.9 – 625.9) | 32.4 cc | 111.1 cc | |
| Mean dose (liver –GTV) | 16.0 Gy (3.0 –23.5 Gy) | 15.5 Gy | 19.2 Gy | <20 Gy |
| V15 | 36% (7.5 –56) | 38% | 37% | |
| rV15cc | 947 cc (524 –2048) | 1221 cc | 883 cc | >700 cc |
| V18 | 33% (7 –49) | 35% | 33% | |
| rV18cc | 1019 cc (634 –2143) | 1289 cc | 941 cc | >800 cc |
| V20 | 31% (7 –49) | 33% | 30% | |
| rV20cc | 1095 cc (668 –2253) | 1324 cc | 977 cc | >700 cc |
| V25 | 25%(5 –40) | 25% | 25% | <36% |
| V30 | 21% (4 – 35) | 17.8% | 21% |
VXX – volume (%) of liver receiving XX Gy or greater. rVXXcc – volume (cc) of liver spared by XX Gy.
a
Patient 1 had a diagnosis of IHC with Child-Pugh class A (score 5) cirrhosis arising from primary sclerosing cholangitis.
b
Patient 2 had a diagnosis of HCC (treated with prior TACE) with Child-Pugh class B (score of 7 secondary to hypoalbuminemia and medication-controlled ascites) cirrhosis in the setting of Hepatitis C.