Fig. 1.

The A_2AR and baicalin alleviated RVSP in the hypoxia-induced PAH mouse model. Effects of baicalin (+Bai, 60 mg/kg/day) and CGS21680 (+CGS, 0.25 mg/kg/day) on RVSP (a; n = 8) and mCAP (b; n = 8) in WT and A_2AR^−/− mice. Representative images of RVSP waves (red) from the WT and A_2AR^−/− groups (c). Representative images of mCAP waves (blue) from the WT and A_2AR^−/− groups (d). Data are presented as the mean ± standard deviation (SD). ^#Value significantly greater than the corresponding value in saline-treated normoxic mice (^# P < 0.05, ^## P < 0.01). *Value significantly less than the corresponding value in hypoxic mice (*P < 0.05, **P < 0.01). ^§Value significantly less than the corresponding value in baicalin-treated mice (^§ P < 0.05, ^§§ P < 0.01). ⁺Value significantly greater than the corresponding value in WT saline-treated mice, WT hypoxic mice, and WT baicalin-treated mice (⁺ P < 0.05, ⁺⁺ P < 0.01). WTH, wild-type hypoxic; A_2AR^−/−H, A_2AR^−/− hypoxic; s, saline-treated