Table 4. Monoamine and metabolite levels (mean ± SEM) in the striatum.

Abbreviations: DOPAC, 3, 4-dihydroxyphenylacetic acid; HVA, homovanillic acid; 3-MT, 3-methoxytyramine; DA, dopamine; DHPG, 3,4-dihydroxyphenylglycol; NE, norepinephrine; 5-HT, serotonin; 5-HIAA, 5-hydroxyindoleacetic acid.

Measure	GD3S+/+		GD3S−/−
	Saline	MPTP	Saline	MPTP
Dopamine	9.16 ± 1.01	3.60 ± 0.46****	9.37 ± 0.92	5.76 ± 0.73**
DOPAC	0.44 ± 0.05	0.23 ± 0.03*	0.52 ± 0.09	0.30 ± 0.04**
HVA	0.72 ± 0.10	0.56 ± 0.06	0.83 ± 0.09	0.70 ± 0.09
3-MT	0.33 ± 0.04	0.21 ± 0.02*	0.27 ± 0.03	0.30 ± 0.05
DOPAC/DA	0.05 ± 0.01	0.07 ± 0.01	0.05 ± 0.01	0.05 ± 0.00
HVA/DA	0.09 ± 0.02	0.16 ± 0.01****	0.09 ± 0.01	0.012± 0.01*
3-MT/DA	0.04 ± 0.01	0.06 ± 0.00***	0.03 ± 0.00	0.05± 0.01***^
Norepinephrine	1.12 ± 0.18	0.94 ± 0.17	1.15 ± 0.29	1.59 ± 0.39
DHPG	1.70 ± 0.18	1.41 ± 0.15	2.22 ± 0.38	1.41 ± 0.11
DHPG/NE	2.73 ± 0.69	2.51 ± 0.84	3.50 ± 1.07	3.10 ± 0.97
DA/NE	10.68 ± 2.47	4.73 ± 0.787**	11.24 ± 1.556	6.00 ± 1.279*
5-HT	0.25 ± 0.03	0.24 ± 0.03	0.34 ± 0.081	0.37 ± 0.055
5-HIAA	0.24 ± 0.029	0.24 ± 0.031	0.27 ± 0.055	0.29 ± 0.042
5-HIAA/5-HT	1.01 ± 0.061	1.04 ± 0.104	0.83 ± 0.091	0.80 ± 0.054^

^*p < .05;

^**p < .01;

^***p < .001;

^****p < .0001 vs. respective saline control.

^{^}p < .05 vs. respective wild-type control.