Representative coimmunostaining of (A) pSmad2 (red, row 1) and vimentin (pink, row 2) and of (B) pERK1/2 (red, row 1) and vimentin (pink, row 2) of myocyte-enriched sections of Fbn1C1039G/+ hearts subjected to sham vs. TAC, with treatment groups. Scale bars: 20 μm; zoom inset: ×2 of nonmyocyte-enriched areas. Blue, DAPI (nuclei); green, lipofuscin (myocytes).