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. 2017 Aug 3;2(15):e92409. doi: 10.1172/jci.insight.92409

Figure 1. Heme biosynthetic genes are upregulated in AML and UROD is a poor prognostic factor.

Figure 1

(A) In St. Jude Children’s Research Hospital pediatric AML patients, MYCN expression strongly correlated with upregulation of heme biosynthesis genes. See also Supplemental Figure 1A. (B) In adult AML patients, UROD and MYCN overexpression predicted poor overall survival, analyzed by log-rank Mantel Cox. (C) AML patients relapse or experience refractory disease more frequently when UROD and MYCN are highly expressed together, as determined by Fisher’s exact test. (D) A positive relationship between UROD and MYCN in AML or normal PBMCs from multiple data sets, as determined by linear regression. (E) Immunoblot analysis of murine hematopoietic progenitors transduced with either an empty vector or a virus expressing a MYCN expression vector, followed by immunoblot analysis of the displayed proteins, UROD and MYCN. Representative images of two experiments. MYCN and Ponceau S images are the same as in Figure 3A. *P < 0.05, **P < 0.01, ***P < 0.001.