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. 2017 Aug 3;2(15):e93358. doi: 10.1172/jci.insight.93358

Figure 4. Cardiac expression of C3-C-GFP suppresses DOX-induced cardiomyopathy.

Figure 4

(A–E) Effects of C3-C-GFP on DOX-induced reduction of heart weight (A), LV systolic (B and C) and diastolic (D) functions, and MDA production (E) in C57BL/6J mouse hearts (n = 3–6). (F) Representative fluorescence images of mouse hearts with or without adenoassociated virus (AAV) encoding C3-C-GFP. Scale bar: 1 mm. (G) Effects of C3-C-GFP on protein abundances of Nox2 and TRPC3 in DOX-treated mouse hearts (n = 3). Data are shown as the mean ± SEM. Significance was determined using one-way ANOVA followed by Tukey’s comparison test. *P < 0.05, **P < 0.01.