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. 2017 Aug 3;2(15):e94488. doi: 10.1172/jci.insight.94488

Figure 1. Metabolic phenotype of URMC099-treated, FFC-fed mice.

Figure 1

WT C57BL/6J mice fed either chow or a diet high in saturated fat, fructose, and cholesterol (FFC) for 24 weeks were randomized to receive either URMC099 or vehicle i.p. twice daily during the last 2 weeks (n = 5–7). (A) Body weight at the time of sacrifice (n = 5–7). (B) Daily caloric intake (calories per day per mouse) during the period of i.p. injection (n = 3). (C) Weight ratio of lean mass (%) and fat mass (%) (n = 7). (D) Energy expenditure (kcal/hour/kg) (n = 7). (E) Physical activity (counts) (n = 7). (F) Respiratory quotient (n = 7). (G) Homeostasis model assessment of insulin resistance (HOMA-IR) calculated from fasting glucose and insulin levels (n = 4–7). (H) Weight loss during the period of i.p. injections (n = 5–7). Data represent mean ± SEM. Differences between the groups were compared using 1-way ANOVA followed by Bonferroni’s multiple comparisons test. ***P < 0.001. ns, non-significant.