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. 2017 Aug 3;2(15):e93434. doi: 10.1172/jci.insight.93434

Figure 4. The anti-Plasmodium antibody response is more robust in high-miR responders.

Figure 4

IgG antibody titers specific to (A) P. falciparum schizont extract (PfSE) or (B) MSP1-42 (42-kDa fragment of merozoite surface 1 [MSP1]) and MSP2 P. falciparum proteins were determined using an ELISA assay in plasma samples collected prior to infection and 28 ± 3 days after the day of infection. (C) IgG subclass responses (IgG1, IgG2, IgG3, and IgG4) were determined for MSP2. (D) Fold-change induction between d0 and d28 in antibody titers was calculated for each subclass against MSP2 and was compared between low- and high-miR responders. (E) IgM fold-change induction between d0 and d28 in response to MSP1, MSP2, MSP3, MSP4, MSP5, and MSP6 was compared between low- and high-miR responders. Data were assessed for significance by nonparametric paired Wilcoxon test (A–C) or nonparametric Mann-Whitney test (D and E). Box-and-whisker plots: boxes show 25th to 75th percentiles, whiskers extend to all data, line within box shows median; low-miR responders n = 9, high-miR responders n = 10. *P < 0.05; **P < 0.01. ns, not significant.