Table 3. Initial and final clinical diagnosis in pathologically diagnosed patients.
| PSP | CBD | MSA-P | PD | FTLD-bvFTD | |
|---|---|---|---|---|---|
|
|
|
|
|
|
|
|
Initial clinical diagnosis % (N / N) |
|||||
| PSP | 25.4 (31/122) | 6.7 (2/30) | 6.3 (2/32) | 0.0 (0/34) | 1.9 (1/52) |
| CBS | 1.6 (2/122) | 0.0 (0/30) | 0.0 (0/32) | 0.0 (0/34) | 0.0 (0/52) |
| MSA | 0.0 (0/122) | 3.3 (1/30) | 6.3 (2/32) | 2.9 (1/34) | 0.0 (0/52) |
| PD | 23.0 (28/122) | 3.3 (1/30) | 71.9 (23/32) | 82.4 (28/34) | 0.0 (0/52) |
| FTD | 9.8 (12/122) | 33.3 (10/30) | 0.0 (0/32) | 0.0 (0/34) | 76.9 (40/52) |
| FTD-MND | 0.0 (0/122) | 0.0 (0/30) | 0.0 (0/32) | 0.0 (0/34) | 7.7 (4/52) |
| MND | 0.8 (1/122) | 0.0 (0/30) | 0.0 (0/32) | 0.0 (0/34) | 1.9 (1/52) |
| Parkinsonism | 11.5 (13/122) | 13.3 (4/30) | 0.0 (0/32) | 2.9 (1/34) | 0.0 (0/52) |
| LBD | 1.6 (2/122) | 0.0 (0/30) | 0.0 (0/32) | 0.0 (0/34) | 0.0 (0/52) |
| NPH | 0.0 (0/122) | 0.0 (0/30) | 3.1 (1/32) | 0.0 (0/34) | 0.0 (0/52) |
| AD | 1.6 (2/122) | 6.7 (2/30) | 0.0 (0/32) | 0.0 (0/34) | 0.0 (0/52) |
| Dementia | 2.5 (3/122) | 6.7 (2/30) | 0.0 (0/32) | 0.0 (0/34) | 3.8 (2/52) |
| Cerebral vasculopathy | 2.5 (3/122) | 3.3 (1/30) | 0.0 (0/32) | 0.0 (0/34) | 0.0 (0/52) |
| Essential tremor | 0.8 (1/122) | 0.0 (0/30) | 0.0 (0/32) | 2.9 (1/34) | 0.0 (0/52) |
| Depression | 4.1 (5/122) | 0.0 (0/30) | 0.0 (0/32) | 0.0 (0/34) | 0.0 (0/52) |
| Mixed | 7.4 (9/122) | 10.0 (3/30) | 6.3 (2/32) | 5.9 (2/34) | 5.8 (3/52) |
| Other | 8.2 (10/122) | 18.8 (6/30) | 6.3 (2/32) | 2.9 (1/34) | 1.9 (1/52) |
|
Final clinical diagnosis % (N / N) |
|||||
| PSP | 62.6 (114/182) | 13.7 (7/51) | 5.9 (3/51) | 7.8 (4/51) | 1.4 (1/69) |
| CBS | 1.6 (3/182) | 27.5 (14/51) | 2.0 (1/51) | 0.0 (0/51) | 2.9 (2/69) |
| MSA | 1.6 (3/182) | 0.0 (0/51) | 70.6 (36/51) | 3.9 (2/51) | 0.0 (0/69) |
| PD | 9.9 (18/182) | 0.0 (0/51) | 11.8 (6/51) | 80.4 (41/51) | 0.0 (0/69) |
| FTD | 3.3 (6/182) | 29.4 (15/51) | 0.0 (0/51) | 0.0 (0/51) | 65.2 (45/69) |
| FTD-MND | 0.0 (0/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 10.1 (7/69) |
| MND | 0.5 (1/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 4.3 (3/69) |
| Parkinsonism | 2.7 (4/182) | 3.9 (2/51) | 2.0 (1/51) | 3.9 (2/51) | 0.0 (0/69) |
| LBD | 0.5 (1/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/69) |
| NPH | 0.0 (0/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/69) |
| AD | 3.8 (7/182) | 3.9 (2/51) | 0.0 (0/51) | 0.0 (0/51) | 5.8 (4/69) |
| Dementia | 2.2 (4/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/69) |
| Cerebral vasculopathy | 0.5 (1/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/69) |
| Essential tremor | 0.0 (0/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/69) |
| Depression | 0.0 (0/182) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/69) |
| Mixed | 8.2 (15/182) | 17.6 (9/51) | 7.8 (4/51) | 3.9 (2/51) | 10.1 (7/69) |
| Other | 2.7 (5/182) | 3.9 (2/51) | 0.0 (0/51) | 0.0 (0/51) | 0.0 (0/69) |
Initial and final clinical diagnosis of autopsy-confirmed patients with PSP, CBD, MSA-P, PD, and FTLD-bvFTD. Data are % (N with specific clinical diagnosis / N with any record of clinical diagnosis) of patients per group. Values in bold indicate the correct clinical diagnosis. Abbreviations: AD, Alzheimer's dementia; bvFTD, behavioral variant of frontotemporal dementia; CBD, corticobasal degeneration; CBS, corticobasal syndrome; FTD, frontotemporal dementia; FTD-MND, frontotemporal dementia with motor neuron disease; FTLD, frontotemporal lobar degeneration; LBD, Lewy body dementia; MSA, multiple system atrophy; MSA-P, multiple system atrophy with predominant parkinsonism; NPH, normal pressure hydrocephalus; PD, Parkinson's disease; PSP, progressive supranuclear palsy.