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. Author manuscript; available in PMC: 2018 Feb 28.

Published in final edited form as: ACS Nano. 2017 Feb 8;11(2):1869–1883. doi: 10.1021/acsnano.6b07895

Assessment of sub-acute lung injury potential of III-V materials in the murine lung, 21 D after initial exposure. The experiment was performed similar to the methods in Figure 4, except that the mice were sacrificed 21 D after the oropharyngeal aspiration of III-V particles and ionic forms at a dose of 0.014 mmol/kg (=2 mg/kg GaAs). The corresponding mass doses are listed in Table 3. The BALF was collected to assess (A) differential cell counts, including macrophages, eosinophils, neutrophils and lymphocytes, (B) pro-fibrogenic PDGF-AA and (C) TGF-β1 levels by ELISA. (D) EMMPRIN and (E) MMP-9 levels were also assessed by ELISA. MUS served as a positive control. (*) p < 0.05 compared to control. (#) p < 0.05 compared to nano-sized III-V particles.

Assessment of sub-acute lung injury potential of III-V materials in the murine lung, 21 D after initial exposure. The experiment was performed similar to the methods in Figure 4, except that the mice were sacrificed 21 D after the oropharyngeal aspiration of III-V particles and ionic forms at a dose of 0.014 mmol/kg (=2 mg/kg GaAs). The corresponding mass doses are listed in Table 3. The BALF was collected to assess (A) differential cell counts, including macrophages, eosinophils, neutrophils and lymphocytes, (B) pro-fibrogenic PDGF-AA and (C) TGF-β1 levels by ELISA. (D) EMMPRIN and (E) MMP-9 levels were also assessed by ELISA. MUS served as a positive control. (*) p < 0.05 compared to control. (#) p < 0.05 compared to nano-sized III-V particles.