Table 1.
Clinical characteristics and diagnostic results in patients infected by Vibrio vulnificus
| No. Age/Sex | Underlying disease | Lesion site | Interval A (day) | Antibiotic administration before admission | Positive culture | Antibiotics | Result | Interval B (day) | Tissue | qPCR (CP) | qPCR (Quantitation) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | LC | Left leg | 1 | No | B (+) | Cefotaxime, doxycycline | Death | 0 | Serum | 30.55 | 1,380 |
| 62/M | W (+) | 0 | Bulla | 18.55 | 1,950,000 | ||||||
| 2 | LC | Right leg | 3 | Yes | B (−) | Cefotaxime, doxycycline | Recovery | 2 | Serum | > 40 | |
| 50/M | DM | W (+) | 3 | Bulla | 17.76 | 9,250,000 | |||||
| 3 | LC | Both legs | 1 | No | B (+) | Cefotaxime, ciprofloxacin | Recovery | 2 | Serum | 34.8 | 16 |
| 81/M | 4 | Fascia | 25.61 | 5,580 | |||||||
| 4 | No | Both legs | 0 | No | B (+) | Cefotaxime, ciprofloxacin | Death | 1 | Serum | 36.16 | 43.8 |
| 50/M | 2 | Bulla | 28.34 | 937 | |||||||
| 5 | MDS | Right arm | 1 | No | B (+) | Nafcillin, ciprofloxacin | Recovery | 0 | Serum | 33.65 | 1,170 |
| 65/F | W (−) | 1 | Bulla | 23.41 | 460,000 | ||||||
| 6 | Chronic alcohol drinker | Both ankles | 2 | No | B (+) | Vancomycin,meropenem | Recovery | 0 | Serum | 34.31 | 500 |
| 57/M | W (−)* | 0 | Swab | 24.27 | 13,400 | ||||||
| 7 | Chronic alcohol drinker | Both legs and buttock | 0 | No | B (−) | Cefotaxime, ciprofloxacin | Death | 0 | Serum | 27.16 | 15,400 |
| 73/M | Lt. W (−) | 0 | Left Bulla | 30.33 | 253 | ||||||
| Rt. W (+) | 1 | Right Bulla | 17.84 | 913,000 | |||||||
| 8 | HBV | Right leg | 1 | No | B (−) | Cefotaxime, ciprofloxacin | Death | 0 | Serum | 31.11 | 2,300 |
| 42/M | W (+) | 0 | Swab | 23.82 | 18,000 | ||||||
| 9 | Chronic alcohol drinker | Right leg | 1 | No | B (+) | Cefotaxime, ciprofloxacin | Death | 0 | Serum | 30 | 6,000 |
| 48/M | W (+) | 0 | Swab | > 40 | |||||||
| 10 | LC | Both legs | 2 | Yes | B (−) | Cefotaxime, ciprofloxacin | Death | 2 | Serum | 32.75 | 63.6 |
| 2 | Bulla | 20.96 | 118,000 | ||||||||
| 60/M | W (−) | ||||||||||
| 11 | LC, HTN | Left leg and wrist | 2 | No | B (−) | Cefotaxime, doxycycline | Recovery | 0 | Serum | 33.07 | 777 |
| 62/M | LC | W (−) | 2 | Bulla | 23.06 | 330,000 | |||||
| 12 | LC | Both legs | 7 | ?† | B (−) | Cefotaxime, doxycycline | Recovery | 0† | Serum | 26.16 | 55,400 |
| 1† | Bulla | 29.79 | 7,230 | ||||||||
| 74/M | W (−) | 2 | Bulla | 20.41 | 1,200,000 | ||||||
| 13 | DM, chronic alcohol drinker | Leg | 4 | Yes | B (−) | Ceftriaxone, doxycycline | Recovery | 3 | Serum | > 40 | 15,300 |
| 53/M | W (−) | 3 | Bulla | 26.06 | |||||||
| 14 | LC, HTN | Letf leg | 3 | Yes | B (−) | Cefotaxime, doxycycline | Recovery | 1 | Serum | 32.47 | 76.5 |
| 48/M | W (−) | 2 | Fascia | 13.74 | 13,400,000 |
B = blood; COPD = chronic obstructive pulmonary disease; DM = diabetes mellitus; HB = hepatitis B; HC = hepatitis C; LC = liver cirrhosis; qPCR = quantitative polymerase chain reaction; W = wound; MDS = myelodysplastic syndrome; HBV = hepatitis B virus infection; HTN = Hypertension. Interval A, time from symptom onset to antibiotic administration; Interval B, time from antibiotic administration to sample collection.
Performed wound culture test after 1 day.
It was unclear whether antibiotics were administered before admission; PCR was performed using serum at the time of admission, a bulla sample on the day after admission, and a bulla sample at 2 days after admission.