Table 1.
Case A | Case B* | Case C | Case D | Case E | Case F | ||
---|---|---|---|---|---|---|---|
Personal information and relations | |||||||
Age and gender | 65, female | 45, male | 40, male | 20, female | 40, female | 33, male | |
Occupation | Farmer | Flower grower | Street cleaner | Office worker | Farmer | Doctor | |
Relationship | N/A | A’s son | A’s son-in-law | C’s daughter | Caring for B | Doctor treating B and C | |
Date of onset | July 6 | July 21 | July 22 | N/A | N/A | N/A | |
Outcome | Fatal | Fatal | Survived | Asymptomatic | Asymptomatic | Asymptomatic | |
Risk factors | |||||||
Direct exposure | |||||||
Blood | N/A | Yes | Yes | No | No | No | |
Soiled coat | N/A | Yes | Yes | No | No | No | |
Mucosa | N/A | Yes | Yes | Yes | Yes | Yes | |
Body fluids | N/A | Yes | Yes | Yes | Yes | Yes | |
Protective measures | |||||||
Washing hands | N/A | No | Yes | No | No | No | |
Glove | N/A | No | No | No | No | No | |
Mask | N/A | No | No | No | No | Yes | |
Clinical tests† | |||||||
Blood counts | |||||||
WBC (×109/L) | 1.83↓ | 3.91↓ | 4.51 | N/A | N/A | N/A | |
PLT (×109/L) | 6↓ | 21↓ | 46↓ | N/A | N/A | N/A | |
Urine routine test | |||||||
Proteinuria | ++ | ++ | − | N/A | N/A | N/A | |
Hematuria | +++ | − | − | N/A | N/A | N/A | |
Serum biochemistry | |||||||
ALT (U/L) | 1,018↑ | 290↑ | 28 | N/A | N/A | N/A | |
AST (U/L) | 2,091↑ | 1,847↑ | 26 | N/A | N/A | N/A | |
LDH (U/L) | 4,602↑ | 4,309↑ | 192 | N/A | N/A | N/A | |
CK (U/L) | 15,268↑ | 9,912↑ | 36 | N/A | N/A | N/A | |
CK-MB (U/L) | 360↑ | 110↑ | 10 | N/A | N/A | N/A | |
Laboratory tests | |||||||
RT-PCR | S | + | + | − | − | − | − |
M | − | − | − | − | − | − | |
L | + | + | − | − | + | + | |
IgM | cELISA‡ | N/A | 512 | 256 | 512 | 2,048 | 1,024 |
IFA | N/A | − | − | − | + | + | |
IgG | cELISA‡ | N/A | 320 | 160 | − | − | − |
IFA | N/A | + | − | − | − | − | |
MNA | N/A | N/A | − | − | 80 | 40 |
ALT = alanine aminotransferase; AST = aspartate aminotransferase; cELISA = Cellular enzyme-linked immunosorbent assayCK = creatine kinase; CK-MB = creatine kinase-MB; IFA = Immunofluorescence assay; LDH = lactate dehydrogenase; MNA = microneutralization assay; N/A = not applicable PLT = platelet count; WBC = white blood cells. + = positive; − = negative. Clinical parameters below the normal range are shown in bold numbers with down arrows; and those over the normal range are shown in bold with up arrows.
Virus was isolated from the serum sample of case B collected on July 30.
Listed are the blood counts on the first day of admission and the serum biochemistry on the last day of admission.
The positive antibody titer was expressed as the reciprocal of the dilution at which the optical density value was three times higher than the negative controls.