Table 1.
Results of gene ontology overrepresentation analysis (ORA)
| GOID | GOTerm | Cluster | Adj.pval | Gene symbols |
|---|---|---|---|---|
| GO:0006099 | Tricarboxylic acid cycle | 1 | 1.90E-03 | Dlst, Idh2, Pdha1 |
| GO:0032675 | Regulation of interleukin-6 production | 2 | 9.60E-05 | Bank1, Hyal2, Il1b, Tlr7, Tnfaip3 |
| GO:0032722 | Positive regulation of chemokine production | 2 | 9.60E-05 | Ffar2, Il1b, Tlr7 |
| GO:0032755 | Positive regulation of interleukin-6 production | 2 | 9.60E-05 | Hyal2, Il1b, Tlr7 |
| GO:0032757 | Positive regulation of interleukin-8 production | 2 | 9.60E-05 | Ffar2, Hyal2, Il1b, Tlr7 |
| GO:0050729 | Positive regulation of inflammatory response | 2 | 9.60E-05 | Alox5ap, CcI6, Ffar2, Hyal2, Il1b |
| GO:0002675 | Positive regulation of acute inflammatory response | 2 | 9.60E-05 | Alox5ap, Ffar2, Il1b |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | 2 | 9.60E-05 | Il18r1, Il1b, Ltbr, Nfkbie, Prkcb, Tlr7 |
| GO:0072604 | Interleukin-6 secretion | 2 | 9.60E-05 | Bank1, Hyal2, Il1b |
| GO:0042307 | Positive regulation of protein import into nucleus | 2 | 9.60E-05 | Hyal2, Il18r1, Il1b, Tlr7 |
| GO:0042346 | Positive regulation of NF-kappaB import into nucleus | 2 | 9.60E-05 | Il18r1, Il1b, Tlr7 |
| GO:0030595 | Leukocyte chemotaxis | 3 | 5.50E-04 | C5ar1, CcI6, Ffar2, Il1b, Jaml, Lgals3, Swap70 |
| GO:0097529 | Myeloid leukocyte migration | 3 | 5.50E-04 | C5ar1, CcI6, Il1b, Jaml, Lgals3, Swap70 |
| GO:0030593 | Neutrophil chemotaxis | 3 | 5.50E-04 | C5ar1, CcI6, Il1b, Jaml, Lgals3 |
| GO:1900077 | Negative regulation of cellular response to insulin stimulus | 4 | 5.50E-04 | Il1b, Mzb1, Prkcb, Trim72 |
| GO:2001236 | Regulation of extrinsic apoptotic signaling pathway | 5 | 2.50E-05 | Hyal2, Il1b, Inhba, Itga6, Lgals3, Ltbr, Tnfaip3, Traf1 |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | 5 | 2.50E-05 | Il1b, Itga6, Lgals3, Tnfaip3 |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | 5 | 2.50E-05 | Hyal2, Inhba, Ltbr |
| GO:0008203 | Cholesterol metabolic process | 6 | 4.70E-03 | Cebpa, Fdft1, Hmgcr, Ldlr |
| GO:0010043 | Response to zinc ion | 7 | 2.10E-03 | Ass1, Hvcn1, Mt1, Mt2A |
Note: Summary table of ClueGO analysis showing overrepresented gene ontology groups. For each enriched GO term, information is provided about: identification of gene ontologies terms (GOID, GO term); the cluster that include the GO term (Cluster); multiple testing adjusted p value obtained with Bonferroni stepwise correction (adj.pval); the genes symbols from the uploaded cluster that were associated with the term (gene symbols).