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Chemical structures and bioconjugation reaction. (a) Bioconjugation steps: TMV-lysine was first reacted with SATP via NHS chemistry, TMV-SATP’s thiol group was then deprotected using hydroxylamine, and finally TMV-SH was reacted with the maleimide group of vcMMAE, resulting in TMV-vcMMAE. (b) Chemical structure of vcMMAE. (A color version of this figure is available in the online journal.)
vcMMAE: valine-citrulline monomethyl auristatin E.
