Skip to main content
. 2017 Aug 4;12(8):e0182646. doi: 10.1371/journal.pone.0182646

Fig 9. Hypothesis for the alternative pathogenic pathway of IMQ-induced skin disease in GM-CSF deficient mice.

Fig 9

GM-CSF has a role as a differentiation factor in DC development; GM-CSF inhibits FLT3L-driven pDC production from lineage-negative DC precursor subsets, while promoting conventional DC growth via modulation of a complex network of transcriptional factors. Thus, the upregulation of the transcription factor E2-2, which is induced by FLT3L, is essential for the development and maintenance of a mature pDC phenotype. However, the E2-2-dependent pDC promoting-transcriptional program can be antagonized by GM-CSF via upregulation of the transcription factor ID2 that directs conventional DC development.