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. 2017 Jul 21;13(7):e1006907. doi: 10.1371/journal.pgen.1006907

Table 2. Biological function annotations of hub genes from human orthologous networks.

Hub Gene Function Summary
BTRC Proteolysis
CFTR regulation of chloride channel activity, cholesterol transport
CTBP1 regulation of histone acetylation
DLG4 regulation of cytosolic calcium concentration, neuronal synaptic plasticity
ELAVL1 regulation of stem cell population maintenance, RNA binding
ENO1 Glycolysis
FBXW11 Proteolysis
FLNA actin skeleton, glycoprotein binding
FN1 calcium-dependent cell-matrix adhesion
FYN metal ion binding, regulation of cell survival
HSPB1 heat shock protein, stress resistance, actin organization
HSPB2 heat shock protein, stress resistance, actin organization
NCOR1 regulation of lipid transport, chromatin binding
NCOR2 regulation of lipid transport, chromatin binding
PRKACA calcium mediated signaling
PTPRK protein localized to cell surface, regulation of cell adhesion, EGFR pathway
RYK neuron differentiation, protein kinase
SMAD9 metal ion binding, bone and brain development
SRC immune response, regulation of cell adhesion and apoptosis, ion channel binding
TJP1 calmodulin binding, cell-cell junction organization
VDR calcium ion transport