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. 2017 Jul 21;13(7):e1006922. doi: 10.1371/journal.pgen.1006922

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© 2017 Vincentz et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — A-K) Section in situ hybridization showing expression of Bmp10 (A, E, I), Irx2 (B, F, J), Dkk3 (C, G, K) in E14.5 embryonic hearts, and X-gal-stained bisected P56 Control (D), Hand1^LV-Cre;Hand1^fx/fx;Hand2^fx/fx (H), and Hand1^LV-Cre;Hand1^fx/fx;Hand2^fx/fx;R26R^DTA-rescued hearts (L). Note that the RV of the heart in panel L has been mechanically damaged. (M, N) Echocardiographic analyses of P56 mice revealed restoration of ejection fraction (M) and fractional shortening (N) in Hand1^LV-Cre(+);Hand1^fx/fx;Hand2^fx/fx;R26R^DTA mice (n = 15) compared to Hand1^LV-Cre(+);Hand1^fx/fx;Hand2^fx/fx CKOs. Hand1^LV-Cre(-);R26R^DTA mice, denoted as DTA(+), are included as controls. Data are represented as mean ± standard error of mean.