Table 1. Cardiac defects in Hand1;Hand2 conditional knockouts at E17.5.
| Genotype | n | VSD | hyperplastic mitral valves | abnormal LV trabeculae | overgrown LV myocardium | Phenotypically Normal |
|---|---|---|---|---|---|---|
| H1fx/fx;H2fx/fx;(-) | 2 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (100%) |
| H1+/fx;H2+/fx;Cre(+) | 6 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 6 (100%) |
| H1+/fx;H2fx/fx;Cre(+) | 4 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 4 (100%) |
| H1fx/fx;H2+/+;Cre(+) | 4 | 2 (50%) | 0 (0%) | 1 (25%) | 0 (0%) | 2 (50%) |
| H1fx/fx;H2+/fx;Cre(+) | 5 | 1 (20%) | 3 (60%) | 3 (60%) | 0 (0%) | 1 (20%) |
| H1fx/fx;H2fx/fx;Cre(+) | 8 | 6 (75%) | 7 (87.5%) | 3 (37.5%) | 5 (62.5%) | 0 (0%) |
VSD–ventricular septal defect.