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. Author manuscript; available in PMC: 2017 Aug 4.
Published in final edited form as: Sci Transl Med. 2017 May 17;9(390):eaah5084. doi: 10.1126/scitranslmed.aah5084

Fig. 1. BET bromodomain inhibition treats preestablished HF after prolonged pressure overload.

Fig. 1

(A) Experimental protocol for preestablished pressure overload model induced by TAC in mice. Veh, vehicle. (B) Ratio of heart weight/tibia length (HW/TL) (n = 10) and (C) lung weight/tibia length (LW/TL) (n = 10). (D) LV ejection fraction, (E) LV diastolic area, and (F) LV wall thickness quantified by echocardiography (n = 10). (IVS + PW)d is the total thickness of the interventricular septum and posterior LV wall at the end-diastole. (G) Representative LV cross sections stained with wheat germ agglutinin (WGA) with quantification of mean cardiomyocyte (CM) cell area shown below (n = 3 to 4). Scale bars, 20 µm. (H) Representative LV cross sections stained with picrosirius red. Scale bars, 400 µm (top) and 100 µm (bottom). Quantification of fibrotic area below (n = 5). (I) Quantitative reverse transcription polymerase chain reaction (qRT-PCR) for indicated genes in mouse heart tissue (n = 5). For (A) to (I), *P < 0.05, **P < 0.01, ***P < 0.001 for indicated comparison. Data are shown as means ± SEM.