Fig. 2.

Fibrillar α-synuclein accelerates the aggregation of Aβ42 through a heterogeneous nucleation process. (A and B) Kinetic profiles of the aggregation reactions of a 2 μM sample of Aβ42 in the absence and presence of increasing concentrations of preformed (A) α-synuclein and (B) Aβ42 fibril seeds (represented by different colors). (C) Half-times of the aggregation reaction profiles as derived from A and B as a function of seed concentrations. Average values were derived from triplicates of each sample in the experiment.