Table 1.
Aortic Chemokine/Cytokine Concentrations (ng/mg aortic protein)
| Young | Old | Old CL | Old CR | Old Rap | |
|---|---|---|---|---|---|
| n | 8 | 29 | 10 | 19 | 23 |
| CCL3 | 1.00 (1.00, 1.51) | 3.40 (0.83, 14.67) | 1.45 (0.66, 6.73) | 10.34 (6.99, 13.30)* | 3.04 (0.09, 8.73) |
| CCL5 | 0.33 (0.33, 0.34) | 0.33 (0.33, 2.59) | 0.33 (0.33, 0.62) | 1.36 (0.47, 2.49)† | 0.33 (0.33, 1.99) |
| CCL11 | 0.30, (0.30, 6.61) | 9.32 (3.73, 13.82) | 13.44 (7.17, 16.29)* | 4.41 (3.26, 5.61) | 10.91 (3.77, 13.09) |
| CXCL2 | 0.64 (0.64, 1.29) | 1.50 (1.06, 2.33) | 1.56 (1.06, 2.99) | 1.50 (1.06, 3.14) | 1.06 (1.06, 2.33) |
| IFN-γ | 0.49 (0.49, 0.49) | 0.49 (0.34, 0.49) | 0.35 (0.34, 0.49) | 0.49 (0.49, 0.49) | 0.49 (0.34, 0.49) |
| IL-2 | 0.27 (0.27, 0.27) | 0.30 (0.21, 0.69 | 0.27 (0.07, 0.62) | 0.36 (0.27, 0.63) | 0.44 (0.27, 0.61) |
| IL-6 | 0.39 (0.39, 0.69) | 0.48 (0.33, 1.03) | 0.33 (0.33, 0.50) | 0.66 (0.39, 0.76) | 0.39 (0.33, 0.54) |
| IL-8 | 0.86 (0.41, 1.13) | 2.00 (0.63, 3.27) | 0.89 (0.61, 1.63) | 2.19 (1.60, 2.96)* | 1.20 (0.70, 2.10) |
| IL-9 | 46.92 (31.64, 64.79) | 30.0 (17.64, 121.49) | 20.57 (10.76, 65.81) | 97.00 (56.11, 131.83)† | 29.29 (17.00, 94.41) |
| IL-12p70 | 0.24 (0.21, 0.36) | 0.74 (0.23, 1.07) | 0.51 (0.31, 0.87) | 0.74 (0.40, 0.94)* | 0.50 (0.22, 0.74) |
CL: crowded litter, CR: caloric restriction, Rap: Rapamycin. Differences were assessed with Kruskal-Wallis one-way ANOVA with Dunn’s pairwise comparisons.
*
Different from Young,
†
different from Old CL, p < 0.05 Data are medians (25th percentile, 75th percentile).