Table 3.

Summary Statistics for the CYP2R1 Low-Frequency Variant, rs117913124, from 19 Studies

Study	25OHD Measurement Method	n	EAF (A Allelea)	Betab	Standard Error	p Value	Information Score
ALSPAC imputed	MS	3,675	0.028	−0.59	0.07	3.43 × 10−18	0.99
ALSPAC WGS	MS	1,606	0.028	−0.65	0.11	8.23 × 10−10	NA
BPROOF	MS	2,512	0.027	−0.4	0.09	4.99 × 10−6	0.97
BMDCS	MS	863	0.019	−0.11	0.06	0.058	0.98
CHS	MS	1,581	0.022	−0.55	0.11	5.15 × 10−7	0.88
FHS	CLIA	5,402	0.021	−0.45	0.07	2.32 × 10−10	0.97
GenerationR	MS	1,442	0.033	−0.66	0.1	1.78 × 10−6	1
GOOD	CLIA	921	0.028	−0.14	0.14	0.31	0.96
MrOS	MS	3,265	0.018	−0.76	0.09	5.63 × 10−16	0.96
MrOS Malmo	CLIA	893	0.033	−0.33	0.14	0.016	0.94
MrOS GBG	CLIA	945	0.026	−0.61	0.14	7.87 × 10−6	1
NEO	MS	5,727	0.025	−0.54	0.06	2.73 × 10−19	1
PIVUS	CLIA	943	0.028	−0.66	0.14	2.56 × 10−6	0.99
RSI	ECLIA	3,320	0.025	−0.19	0.08	0.019	0.98
RSII	ECLIA	2,022	0.033	−0.37	0.09	2.38 × 10−5	0.99
RSIII	ECLIA	2,913	0.027	−0.51	0.08	4.61 × 10−10	0.98
TUK imputed	CLIA	1,919	0.021	−0.1	0.11	0.35	0.98
TUK WGS	CLIA	1,013	0.025	−0.39	0.14	0.006	NA
ULSAM	MS	1,095	0.025	−0.33	0.14	0.02	1

Abbreviations are as follows: CLIA, chemiluminescence immunoassay; EAF, effect allele frequency; ECLIA, electrochemiluminescence immunoassay; MS, mass spectrometry; NA, not applicable; 25OHD, 25-hydroxyvitamin D.

^aEffect allele is the 25OHD decreasing allele.

^bBeta values represent changes in standard deviations of the standardized log-transformed 25OHD levels.