Table 4.

Effect of Different Haplotype Combinations of the Low-Frequency (rs117913124) and Common (rs10741657) CYP2R1 Variants on 25OHD Levels

Haplotypea	Betab	p Value	n
GA GA	−0.02	0.79	156
AG GA	−0.49	0.02	23
AG GG	−0.3	0.13	27
GA GG	0.01	0.87	477
GG GG	0.05	0.58	330

Results are based on individuals from the TUK WGS cohort.

^aThe first allele in each chromatid corresponds to the low-frequency variant rs117913124; the second allele corresponds to the common variant rs10741657. The two AG blocks contain the 25OHD decreasing allele (A) of the low-frequency variant, which is always inherited with the 25OHD decreasing allele (G) of the common variant.

^bBeta values represent changes in standard deviations of the standardized log-transformed 25OHD levels.