Table 5.
Main Findings of the GWAS Meta-analysis
SNP | Chr | Candidate Gene | EA | EAF | Betaa | p Value | n |
---|---|---|---|---|---|---|---|
rs117913124 | 11 | CYP2R1 | A | 0.025 | −0.43 | 1.5 × 10−88 | 41,336 |
rs3819817 | 12 | HAL | C | 0.45 | 0.04 | 3.2 × 10−10 | 41,071 |
rs2277458 | 14 | GEMIN2 | G | 0.21 | −0.05 | 6.0 × 10−9 | 39,746 |
Abbreviations are as follows: Chr, chromosome; EA, effect allele; EAF, effect allele frequency; SNP, single-nucleotide polymorphism.
Beta values represent changes in standard deviations of the standardized log-transformed 25OHD levels while controlling for age, sex, BMI, and season of measurement.