Skip to main content
. 2017 Jul 27;101(2):218–226. doi: 10.1016/j.ajhg.2017.06.015

Table 1.

Correlation Coefficients between Predicted Scores and Observed Lipid Concentration in African Americans of the Women’s Health Initiative SNP Health Association Resource

Trait | C1| VG/VP XP-BLUP LMM Age BMI FE
LDL 413 0.33 0.18 0.095 0.085 0.044 0.16
HDL 569 0.28 0.22 0.086 0.042 0.21 0.17
TG 413 0.26 0.17 0.078 0.066 0.11 0.13

All correlations are evaluated on the African American testing set individuals. Abbreviations are as follows: | C1|, number of SNPs in C1 set; VG/VP, SNP-heritability estimated by program GCTA; XP-BLUP, proposed trans-ethnic best linear unbiased prediction; C1 SNPs are defined by p < 5 × 10−8 in Global Lipids Genetics Consortium (GLGC) meta-analysis; LMM, standard linear mixed effects model computed by GCTA; age, fixed effects model with age as a single predictor; BMI, fixed effects model with BMI as a single predictor; FE, fixed effects model that includes only index SNPs at genome-wide significant loci in the African American training set.