Table 1.
Trait | | C1| | VG/VP | XP-BLUP | LMM | Age | BMI | FE |
---|---|---|---|---|---|---|---|
LDL | 413 | 0.33 | 0.18 | 0.095 | 0.085 | 0.044 | 0.16 |
HDL | 569 | 0.28 | 0.22 | 0.086 | 0.042 | 0.21 | 0.17 |
TG | 413 | 0.26 | 0.17 | 0.078 | 0.066 | 0.11 | 0.13 |
All correlations are evaluated on the African American testing set individuals. Abbreviations are as follows: | C1|, number of SNPs in C1 set; VG/VP, SNP-heritability estimated by program GCTA; XP-BLUP, proposed trans-ethnic best linear unbiased prediction; C1 SNPs are defined by p < 5 × 10−8 in Global Lipids Genetics Consortium (GLGC) meta-analysis; LMM, standard linear mixed effects model computed by GCTA; age, fixed effects model with age as a single predictor; BMI, fixed effects model with BMI as a single predictor; FE, fixed effects model that includes only index SNPs at genome-wide significant loci in the African American training set.