Table 2.

Predictors of mortality (Cox regression).

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	p	HR	95%CI	p
Age at diagnosis
continuous	1.02	0.99–1.06	0.19	1.01	0.97–1.05	0.71
Gender (v male)
female	0.89	0.35–2.26	0.80	1.48	0.52–4.17	0.46
Race (v white)
on-whiten	1.49	0.62–3.54	0.37	1.54	0.47–5.01	0.48
KPS (v ≥90)
<90	2.88	1.46–5.66	<0.01	3.95	1.79–8.74	<0.01
T-classification (v T1–T2)
T3–T4	2.64	1.41–4.97	<0.01	1.85	0.87–3.95	0.11
N-classification (v N0–1)
N2–N3	1.75	0.84–3.68	0.14	2.40	0.93–6.22	0.07
Tobacco use (v ≤10 pack-years)
>10 pack-years	3.01	1.38–6.54	<0.01	3.18	1.10–9.15	0.03
HPV status (v negative)
positive	0.38	0.18–0.81	0.01	0.34	0.12–0.96	0.04
unknown	0.65	0.30–1.41	0.27	0.33	0.12–0.87	0.03
Site (v oropharynx)
larynx	0.97	0.47–1.98	0.93	0.45	0.17–1.20	0.11
Chemotherapy (v CRT)
BRT	2.19	1.03–4.63	0.04	1.19	0.42–3.35	0.74

Abbreviations: CRT, chemoradiotherapy; BRT, bioradiotherapy; KPS, Karnofsky performance status; HPV, human papillomavirus; HR, hazard ratio; 95%CI, 95% confidence interval.