Fig. 4.

Results from the sensitivity analysis. Relative sensitivity of estimated ONH mechanical properties and biomechanics (columns) on measurable (rows labeled in blue) and potentially measurable parameters (rows labeled in green). Disc areas are proportional to the percentage of an output variance due to each of the parameters, such that larger discs represent a stronger sensitivity of the response to the factor. Discs are black for positive covariations and gray for negative ones. The covariance and redundancy in parameters meant that sensitivity to one parameter implied some sensitivity to the covariates. Hence, multiple parameters shared influence patterns. Similarly, multiple outputs of interest had essentially the same parameter sensitivities. A representative set of outputs and parameters are shown, to avoid duplication and keep the plot clear. Note the strong sensitivities of estimated IOP-induced strains to parameters representing sclera deformations such as canal expansion.