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Schematic illustration of a HAdase-activatable theranostic system. A cationic conjugated polymer (PFEP) forms a complex with hyaluronic acid (HA) conjugated with a drug (DOX). Electron transfer (ET) from PFEP to DOX occurs in this complex, leading to a quenched fluorescence emission. At the present of HAase in cancer cells, HA is degraded and DOX is released, resulting in the turn on signal of PFEP. Reproduced with permission.[92] Copyright 2015, American Chemical Society.
