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Hypoxia-driven turn on theranostics.
| Bioactive link/group | Signal reporter | Therapeutic agent | Imaging modality | Therapeutic modality | Ref. |
|---|---|---|---|---|---|
| 4-nitrobenzyl | 7-N,N-diethylaminocoumarin | Gemcitabine | FLI | CHT | 178 |
| 4-nitrobenzyl | SN38 | SN38 | FLI | CHT | 179 |
| 2-nitroimidazole | DOX | DOX | FLI | CHT | 180 |
| 4-nitrobenzyl | DOX | DOX | FLI | CHT | 181 |
| 2-nitroimidazole | 7-aminocoumarin | Etoposide | FLI | CHT | 182 |
| 2-nitroimidazole | DOX | DOX/CP-NI | FLI | CHT/PDT | 183 |
