Table 1. Baseline and tumor characteristics of participants by depression at WHI baseline and Year three (n=3095).
| Variable | Depression at baseline | Depression at baseline and Year three | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Depression | No depression | P value | No at both time points | Baseline only | Year three only | Yes at both time points | P value | |
| Total number of women | 357 | 2738 | 2533 | 176 | 205 | 181 | ||
| Characteristics of participants | ||||||||
| Age at baseline (mean±SD, yrs) | 61.2±6.8 | 63.4±7.0 | <0.001 | 63.5±7.0 | 62.3±6.7 | 61.8±7.0 | 60.2±6.7 | <0.001 |
| White, non-Hispanic-ethnicity (%) | 90.2 | 90.4 | 0.887 | 90.5 | 90.3 | 89.8 | 90.1 | 0.986 |
| Body mass index (mean±SD, kg/m2) | 28.7±6.6 | 27.0±5.4 | <0.001 | 26.9±5.4 | 28.1±6.5 | 28.0±5.9 | 29.3±6.7 | <0.001 |
| Physical inactivity (mean±SD, METs/wk) | 11.9±12.8 | 13.9±13.1 | 0.006 | 14.0±13.1 | 11.5±12.5 | 12.5±12.6 | 12.3±13.2 | 0.002 |
| Smoking status (%) | 0.008 | 0.021 | ||||||
| Never smokers | 41.4 | 48.2 | 48.5 | 41.5 | 43.9 | 41.2 | ||
| Former smokers | 49.9 | 46.3 | 46.2 | 51.1 | 47.8 | 48.6 | ||
| Current smokers | 8.8 | 5.5 | 5.3 | 7.4 | 8.3 | 10.2 | ||
| Alcohol intake (7+ drinks/wk, %) | 41.7 | 45.5 | 0.176 | 46.2 | 38.1 | 36.6 | 45.3 | 0.013 |
| History of postmenopausal hormone therapy (%) | 72.0 | 64.9 | 0.008 | 64.9 | 65.9 | 64.9 | 77.9 | 0.005 |
| Comorbidity index (%) | 0.008 | 0.009 | ||||||
| 0 | 17.1 | 22.0 | 22.1 | 17.1 | 20.5 | 17.1 | ||
| 1 | 26.1 | 30.2 | 30.6 | 30.1 | 25.4 | 22.1 | ||
| 2 | 28.0 | 25.4 | 25.5 | 27.3 | 24.9 | 28.7 | ||
| 3+ | 28.9 | 22.4 | 21.8 | 25.6 | 29.3 | 32.0 | ||
| Mammography during last two years (%) | 88.5 | 91.3 | 0.081 | 91.7 | 89.5 | 86.9 | 87.5 | 0.037 |
| Mammography interval (%) | 0.342 | 0.160 | ||||||
| <1 year | 59.2 | 62.8 | 63.2 | 57.9 | 57.8 | 60.5 | ||
| 1 to <2 years | 27.9 | 27.2 | 27.1 | 31.0 | 27.6 | 24.9 | ||
| 2 to <5 years | 8.3 | 6.8 | 6.6 | 8.2 | 9.1 | 8.5 | ||
| ≥5 years (or never) | 4.6 | 3.3 | 3.1 | 2.9 | 5.5 | 6.2 | ||
| Tumor Characteristics | ||||||||
| Tumor stage (%) | 0.397 | 0.809 | ||||||
| Localized | 74.0 | 77.0 | 77.0 | 76.1 | 76.6 | 71.8 | ||
| Regional | 24.9 | 21.8 | 21.7 | 22.7 | 22.4 | 27.1 | ||
| Distant | 1.1 | 1.2 | 1.3 | 1.1 | 1.0 | 1.1 | ||
| Tumor grade (%) | 0.676 | 0.892 | ||||||
| Low | 30.6 | 29.0 | 28.9 | 31.5 | 30.4 | 29.8 | ||
| Intermediate | 43.5 | 46.1 | 46.2 | 40.6 | 44.5 | 46.4 | ||
| High | 25.8 | 24.9 | 27.9 | 27.9 | 25.1 | 23.8 | ||
| ER and PR status (%) | 0.455 | 0.374 | ||||||
| ER+PR+ | 67.8 | 70.9 | 71.1 | 64.9 | 69.4 | 70.5 | ||
| ER-PR+/ER+PR- | 18.1 | 15.8 | 16.0 | 20.0 | 13.3 | 16.2 | ||
| ER-PR- | 14.2 | 13.3 | 13.0 | 15.2 | 17.4 | 13.3 | ||
WHI: Women's Health Initiative; SD: Standard deviation; ER: estrogen receptor; PR: progesterone receptor