Table 4. Hazard ratios (HRs) and 95% confidence interval (CIs) for breast cancer outcome in relation to depression and depressive symptoms stratified by tumor stage^*.

Variable	n	All-cause mortality			Breast cancer mortality
		Cases	HR	95%CI	Cases	HR	95%CI
Depressiona
Tumor stage
Localized
No at both points	1951	287	1		63	1
Baseline only	134	19	0.93	0.56-1.55	3	0.74	0.23-2.40
Year three only	157	22	1.05	0.66-1.69	2	0.46	0.11-1.89
Yes at both points	130	17	1.46	0.82-2.60	3	0.90	0.21-3.77
Regional or distant
No at both points	582	150	1		87	1
Baseline only	42	13	1.09	0.54-2.19	5	0.43	0.10-1.79
Year three only	48	17	2.00	1.13-3.56	13	2.42	1.24-4.70
Yes at both points	51	17	1.23	0.67-2.24	11	1.28	0.59-2.78
Depressive symptomsb
Tumor stage
Localized
No at both points	2034	297	1		65	1
Baseline only	140	19	0.95	0.57-1.59	4	0.96	0.34-2.70
Year three only	118	14	0.93	0.52-1.67	0
Yes at both points	80	15	1.92	1.03-3.58	2	0.82	0.11-6.08
Regional or distant
No at both points	608	159	1		93	1
Baseline only	41	12	1.08	0.52-2.25	5	0.42	0.10-1.74
Year three only	45	16	2.14	1.18-3.88	11	2.46	1.23-4.90
Yes at both points	29	10	1.24	0.57-2.70	7	1.27	0.45-3.55

^*Adjusted for age, race, body mass index, smoking, history of postmenopausal hormone therapy, comorbidity, mammography use, tumor grade, and estrogen receptor & progesterone receptor status.

^a“Depression” includes depressive symptoms or anti-depressant use.

^b“Depressive symptoms” refers to depressive symptoms only.