Table 1.
Baseline characteristics of patients enrolled in the TOPCAT trial included versus not included in this analysis.
| Nonecho n=3021 | Echo including T2P LS n=424 | P-value | |
|---|---|---|---|
| Demographics | |||
| Age (years) | 68.3 ± 9.5 | 70.2 ± 9.8 | <0.001 |
| Women, n (%) | 1542 (51.1%) | 231 (54.5%) | 0.19 |
| White, n (%) | 2721 (90.2%) | 339 (80.0%) | <0.001 |
| Enrollment in Russia/Georgia, n (%) | 1573 (52.1%) | 105 (24.8%) | <0.001 |
| Clinical | |||
| Enrollment strata: previous hospitalization, n (%) | 2192 (72.6%) | 271 (63.9%) | <0.001 |
| Myocardial Infarction, n (%) | 782 (25.9%) | 111 (26.2%) | 0.89 |
| Coronary revascularization, n (%) | 687 (22.8%) | 126 (29.8%) | 0.001 |
| Stroke, n (%) | 222 (7.4%) | 43 (10.2%) | 0.043 |
| Atrial fibrillation, n (%) | 1037 (34.4%) | 176 (41.6%) | 0.004 |
| Diabetes mellitus, n (%) | 957 (31.7%) | 161 (38.1%) | 0.009 |
| Hypertension, n (%) | 2756 (91.4%) | 389 (92.0%) | 0.69 |
| NYHA functional class (3 & 4), n (%) | 974 (32.3%) | 161 (38.2%) | 0.017 |
| QRS Duration (ms) | 99.4 ± 28.4 | 100.9 ± 27.1 | 0.32 |
| QRS duration > 120 ms | 552 (18.3%) | 84 (19.8%) | 0.44 |
| BMI (kg/m2) | 32.1 ± 7.3 | 32.5 ± 6.9 | 0.30 |
| Heart Rate (beats per minute) | 69.1 ± 10.3 | 68.7 ± 10.8 | 0.41 |
| Systolic blood pressure (mmHg) | 129.6 ± 13.7 | 126.5 ± 15.2 | <0.001 |
| Diastolic blood pressure (mmHg) | 76.2 ± 10.5 | 72.6 ± 10.8 | <0.001 |
| Lab work | |||
| Creatinine (mg/dL) | 1.1 ± 0.3 | 1.1 ± 0.3 | 0.002 |
| Z score BNP | 0.0 ± 1.0 | −0.1 ± 1.0 | 0.30 |