Table 4.

Measures of Mechanical Dyssynchrony and the association with outcome

	N	Events	Hazard Ratio (95% CI)	P-value
Obtained from the 4CH view
SD T2P LS per 10 ms increase
Unadjusted	424	107	1.04 (1.01–1.07)	0.021
Model 1	424	107	1.03 (1.00–1.06)	0.055
Model 2	410	105	1.03 (0.99–1.06)	0.157
SD T2P TS per 10 ms increase
Unadjusted	424	107	1.00 (0.98–1.03)	0.785
Model 1	424	107	1.00 (0.98–1.03)	0.838
Model 2	410	105	1.00 (0.98–1.03)	0.840
Obtained from the 4CH and 2CH view
Average of SD T2P LS per 10 ms increase
Unadjusted	212	50	1.07 (1.00–1.15)	0.046
Model 1	212	50	1.06 (0.99–1.14)	0.083
Model 2	202	49	1.07 (0.99–1.16)	0.083
Obtained from the psax view
SD T2P CS per 10 ms increase
Unadjusted	243	69	1.05 (0.99–1.11)	0.094
Model 1	243	69	1.05 (0.99–1.11)	0.093
Model 2	232	68	1.05 (0.99–1.11)	0.133
SD T2P RS per 10 ms increase
Unadjusted	243	69	0.99 (0.95–1.02)	0.467
Model 1	243	69	1.00 (0.96–1.04)	0.937
Model 2	232	68	1.00 (0.96–1.04)	0.925
T2P anteroseptal to posterior difference per 10 ms increase
Unadjusted	243	69	0.99 (0.97–1.01)	0.495
Model 1	243	69	1.00 (0.97–1.02)	0.784
Model 2	232	68	0.99 (0.97–1.02)	0.499
T2P anteroseptal to posterior difference > 130 ms
Unadjusted	243	69	1.05 (0.56–1.95)	0.889
Model 1	243	69	1.12 (0.60–2.11)	0.719
Model 2	232	68	1.01 (0.52–1.97)	0.970

Model 1 is adjusted for age, sex, race, randomization strata (previous HF hospitalization or biomarker criteria), region of enrollment (Americas versus Russia/Georgia), randomized treatment. Model 2 includes the same variables as Model 1 + core laboratory left ventricular LVEF, history of atrial fibrillation, heart rate, New York Heart Association class, history of stroke, creatinine, hematocrit and QRS duration.