Table 3.
GWIS replication results for FEV1 in CAMP and the GACRS
| CAMP Whites | CAMP Hispanics | GACRS | COMBINED P-VAL | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | A1 | BETA | P-VAL | MAF | n | A1 | BETA | P-VAL | MAF | n | A1 | BETA | P-VAL | MAF | n | All cohorts | Replication only |
| rs117902240 | C | −0.43 | 0.051 | 0.01 | 8/1 | C | −0.61 | 0.011 | 0.03 | 2/1 | C | 0.26 | 0.15 | 0.01 | 2/5 | 7.4E-09 | 0.0065 |
| rs 1404568 | G | −0.0078 | 0.45 | 0.11 | 76/23 | G | 0.048 | 0.32 | 0.17 | 13/3 | G | −0.12 | 0.048 | 0.18 | 20/167 | 1.6E-06 | 0.13 |
| rs72716237 | A | 0.067 | 0.33 | 0.02 | 22/3 | A | NA | NA | NA | NA | A | −0.38 | 0.046 | 0.01 | 2/14 | 1.3E-06 | 0.079 |
| rs7541272 | G | −0.105 | 0.25 | 0.02 | 16/3 | G | NA | NA | NA | NA | G | 0.24 | 0.21 | 0.02 | 1/20 | 4.1E-06 | 0.21 |
| rs35312258 | G | 0.031 | 0.32 | 0.09 | 63/19 | G | 0.048 | 0.33 | 0.17 | 13/3 | G | −0.12 | 0.046 | 0.17 | 19/159 | 3.8E-06 | 0.098 |
Models included the main effects of genotype (additive) and dust mite allergen level (dichotomized <2 vs ≥2 μg/g) and the interaction term (genotype*dust mite allergen level), and were additionally adjusted for age, sex, study site, height, height2, and principal components. SNP=single nucleotide polymorphism; A1=minor allele; BETA=beta coefficient for interaction term; P-VAL=interaction p-value; MAF=minor allele frequency; n=number of subjects with at least one copy of the minor allele and low/high dust mite exposure; NA=not available (genotyped or imputed).