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Showing some common mutations and their IC50 values and fold increase with respect to the IC50 value of wild type reported in literature [9]
| Mutation | Imatinib | Nilotinib | Dasatinib |
|---|---|---|---|
| Wild type | 1 | 1 | 1 |
| M351T | 1.8 | 0.4 | 0.9 |
| T315I | >25 | >150 | >250 |
| H396R | 3.9 | 3.1 | 1.6 |
| F359V | 7.0 | 13.5 | 2.8 |
| M244V | 7.7 | 2.9 | 1.6 |
| Y253H | >25 | 35 | 1.6 |
| E255K | 20 | 15 | 7 |
| E255V | >25 | 33.1 | 13.8 |
